The microbiome is a complex ecosystem living in a fluctuating state of disruption. Bioactive Totarol™ is changing that.
Hyperganic, leaders in sustainable Bioactive Totarol™ innovation are pioneering molecular technology for the next generation of health and beauty products. Bioactive Totarol™ is the breakthrough bioactive built on 30+ years of biotechnology research, studied by global research institutes and utilised by world leading brands.
learn moreWhy formulators choose it
The ingredient changing skin science — and what that means for your product.
4-in-1 Mechanism
Antimicrobial, anti-inflammatory, antioxidant and microbiome-preserving. One ingredient. Three validated actions. One compelling claim story.
learn more4-in-1 Mechanism
Antimicrobial, anti-inflammatory, antioxidant and microbiome-preserving. One ingredient. Three validated actions. One compelling claim story.
learn moreBioactive Totarol™ is an aromatic diterpenoid with chemical formula C20H30O
Targeted, not disruptive. Intelligence, not intervention.
Most skincare actives fight bacteria by eliminating them. Bioactive Totarol™ does something far more sophisticated — it reads the environment of the skin and responds selectively by targeting pathogenic bacteria and preserving the commensal microbiome, reducing inflammation at its source.
Our range
Bioactive Totarol™ supports clinically-backed claims across microbiome balance, barrier function, visible skin improvement, and anti-inflammatory action. Our formulation support team works alongside your R&D to integrate the science into your product development process — not just deliver an ingredient to your door.
Used by:
From lab to skin. The science holds at every level.
Most bioactives perform well in a petri dish. Bioactive Totarol™ performs consistently from in-vitro through to clinical outcome — a continuity of evidence that is rare in the industry and critical for building defensible product claims.
In vitro
Potent antimicrobial activity confirmed against key acne-associated bacteria. Membrane disruption and metabolic inhibition validated.
In vivo microbiome
Preservation of overall microbial diversity confirmed. Selective modulation — not eradication — demonstrated in real skin conditions.
Clinical
Visible reductions in inflammatory lesions, erythema, and barrier dysfunction. Outcomes that align directly with the underlying mechanistic profile.
Testing subject quote
"Please share the brand name as this alone helped clear my moderate acne and rosacea. My cheeks are not inflamed anymore, as long as I use the product. No other serum/cream has done that for me yet"
Raw natural power.
The science is clean. So is the source.
The Tōtara has stood in New Zealand's forests for thousands of years — and it does so because of an extraordinary natural phenomenon. After approximately 150 years of growth, the tree develops a dense concentration of bioactive compounds in its heartwood: a self-made defence system so potent it renders the wood impervious to rot, even long after the tree has fallen. Bioactive Totarol™ is that defence system — unlocked, validated, and put to work for human skin.
Researched by:
- Unilever
- P&G
- Colgate-Palmolive
- University of Medical Sciences Iran
- Otago University NZ
- University of California USA
- University of Tsukuba Japan
Bioactive Totarol™ is extracted using our patented supercritical CO₂ extraction process.
Bioactive Totarol™ is extracted from naturally fallen New Zealand Tōtara wood — a government-sanctioned resource that would otherwise be treated as green waste. Our patented supercritical CO₂ extraction process delivers exceptional purity and batch-to-batch consistency within a closed-loop system. Zero compromise between scientific rigour, supply integrity, and environmental responsibility.
“Rather than disrupting the skin's microbial ecosystem, we are working with it — selectively targeting pathogenic activity while preserving commensal balance and reducing inflammatory signalling. This allows for more stable, long-term outcomes.”
Solve your business problem
Why leading formulators are turning to Bioactive Totarol™
The skincare market is shifting. Consumers are demanding microbiome-friendly formulations, ingredient transparency, and products that work without compromising long-term skin health. Bioactive Totarol™ is built for exactly that moment.